Description

Like DNA, RNA also can carry chemical modifications. N 6‐methyladenosine (m6A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification. m6A methylation regulates gene expression by influencing numerous aspects of mRNA metabolism, including pre‐mRNA processing, nuclear export, decay, and translation.

Display Conventions

Methylated sites are highlighted.

Data Access

todo.

Methods

For the fetal data from Xiao 2019, data was downloaded from NCBI GEO GSE114150 in bed format and merged with a custom Python script.

Credits

Thanks to Natacha Clairet and Guillaume Riviere for paper suggestions.

References

Xiao S, Cao S, Huang Q, Xia L, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W et al. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nat Cell Biol. 2019 May;21(5):651-661. PMID: 31036937