Description

This track contains mutations in the Spike protein that attenuate monoclonal and serum antibody neutralization. Nineteen neutralizing monoclonal antibodies (mAbs) against the receptor binding domain (RBD) were used in a selection screen to generate 48 escape mutants.

Display Conventions and Configuration

Features are labeled with the nucleotide and protein coordinates and the name of the antibody. Click a feature or mouse-over a feature to show these annotations.

Methods

Table 2 from Liu et al 2020, was copied manually and converted to bedGraph format.

Data Access

The raw data can be explored interactively with the Table Browser, or combined with other datasets in the Data Integrator tool.

Please refer to our mailing list archives for questions, or our Data Access FAQ for more information.

References

Zhuoming Liu, Laura A. VanBlargan, Paul W. Rothlauf, Louis-Marie Bloyet, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, Elitza S. Theel, Ali H. Ellebedy, Daved H. Fremont, Michael S. Diamond, Sean P. J. Whelan Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Biorxiv. 2020