This file is from:

This directory contains conversation scoring by phyloP (phylogenetic p-values)
from the PHAST package ( for multiple
alignments of 3 genomes to the mouse genome (mm10, Dec. 2011)

Files in this directory are:

    mm10.phyloP4way.mod  phyloP tree model with branch lengths
                        for the 4 genomes
    mm10.phyloP4way.wigFix.gz - phyloP scores for the 4 genomes
                                 in fixed step wiggle format - phyloP scores for the 4 species
                          in bigWig format
    md5sum.txt - md5 sums of the files here to verify accurate download

The multiple alignments and methods description are at:

For more information about this data, see the track
description for the Conservation track:

For a description of the phyloP wigFix data file format, see:
see also the section describing the 'fixedStep' wiggle format:

Assemblies used in these alignments:

Mouse              Mus musculus             Dec. 2011 (GRCm38/mm10) (reference)

Malayan flying lemur Galeopterus variegatus Jun. 2014 (WashU/galVar1)
Human              Homo sapiens             Dec. 2013 (GRCh38/hg38)
Chinese tree shrew Tupaia chinensis         Jan. 2013 (BGI TupChi1_1.0/tupChi1)

To download a large file or multiple files from this directory, we recommend 
that you use rsync or ftp rather than downloading the files via our website.
There is approximately 3.6 Gb of compressed data in this directory.

Via rsync:
rsync -avz --progress \
	rsync:// ./

Via FTP:
    user name: anonymous
    password: <your email address>
    go to the directory goldenPath/mm10/phyloP4way

To download multiple files from the UNIX command line, use the "mget" command. 
    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all the files in the directory) 
Use the "prompt" command to toggle the interactive mode if you do not want 
to be prompted for each file that you download.

All the files in this directory are freely available for public use.
For data use restrictions regarding the genome assemblies used in this
annotation, see

References for phastCons and phyloP:

Pollard KS, Hubisz MJ, Siepel A. Detection of non-neutral substitution rates
on mammalian phylogenies. Genome Res. 2010 Jan;20(1):110-21.

Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson
H, Spieth J, Hillier LW, Richards S, et al. Evolutionarily conserved elements
in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005
Aug;15(8):1034-50.  (

      Name                      Last modified      Size  Description
Parent Directory - md5sum.txt 2017-04-21 21:03 167 2017-04-21 15:04 2.3G mm10.phyloP4way.mod 2017-04-21 12:22 391 mm10.phyloP4way.wigFix.gz 2017-04-21 12:39 1.3G