This directory contains alignments of the following assemblies:

  - target/reference: Cow (bosTau2, Mar. 2005, Baylor Btau_2.0)

  - query: Rat (rn4, Nov. 2004, Baylor HGSC v. 3.4)

Files included in this directory:

  - md5sum.txt: md5sum checksums for the files in this directory

  - bosTau2.rn4.all.chain.gz: chained blastz alignments. The chain format is
    described in http://genome.ucsc.edu/goldenPath/help/chain.html .

  - bosTau2.rn4.net.gz: "net" file that describes rearrangements between 
    the species and the best Rat match to any part of the
    Cow genome.  The net format is described in
    http://genome.ucsc.edu/goldenPath/help/net.html .

  - bosTau2.rn4.net.axt.gz: chained and netted alignments,
    i.e. the best chains in the Cow genome, with gaps in the best
    chains filled in by next-best chains where possible.  The axt format is
    described in http://genome.ucsc.edu/goldenPath/help/axt.html .

The chainSwap program was used to translate rn4-referenced chained blastz
alignments to bosTau2 into bosTau2-referenced chains aligned to rn4.  See
the download directory goldenPath/rn4/vsBosTau2/README.txt for more
information about the rn4-referenced blastz and chaining process.

Chained alignments were processed into nets by the chainNet, netSyntenic,
and netClass programs.
Best-chain alignments in axt format were extracted by the netToAxt program.
All programs run after blastz were written by Jim Kent at UCSC.

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If you plan to download a large file or multiple files from this directory,
we recommend you use ftp rather than downloading the files via our website.
To do so, ftp to hgdownload.cse.ucsc.edu, then go to the directory
goldenPath/bosTau2/vsRn4/. To download multiple files, use the "mget"
command:

    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all files in the current directory)

All files in this directory are freely available for public use.

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References

Chiaromonte, F., Yap, V.B., and Miller, W.  Scoring pairwise genomic
sequence alignments.  Pac Symp Biocomput 2002, 115-26 (2002).

Kent, W.J., Baertsch, R., Hinrichs, A., Miller, W., and Haussler, D.
Evolution's cauldron: Duplication, deletion, and rearrangement in the
mouse and human genomes. Proc Natl Acad Sci USA 100(20), 11484-11489
(2003).

Schwartz, S., Kent, W.J., Smit, A., Zhang, Z., Baertsch, R., Hardison, R.,
Haussler, D., and Miller, W.  Human-mouse alignments with BLASTZ</A>.
Genome Res. 13(1), 103-7 (2003).

      Name                     Last modified      Size  Description
      Parent Directory                              -   
      md5sum.txt               2006-04-02 15:25  176   
      bosTau2.rn4.net.gz       2006-04-02 15:07  126M  
      bosTau2.rn4.net.axt.gz   2006-03-30 15:44  477M  
      bosTau2.rn4.all.chain.gz 2006-03-30 15:08  186M