gantt
dateFormat MM
axisFormat %U
title Color Key for Milestones
section Examples
Grey = completed milestone : done, milestone, hold1, 2025-03-31, 0d
Light blue = active milestone (have data, not all metadata) : active, milestone, hold2, 2025-4-15, 0d
Red = due milestone : crit, milestone, hold3, 2025-05-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC1 UCLA [RM1MH132651]
section Grant Year
Start Grant Year 3 : milestone, year3_ucla, 2025-03-31, 0d
Start Grant Year 4 : milestone, m1, 2026-03-31, 0d
Start Grant Year 5 : milestone, m1, 2027-03-31, 0d
click year3_ucla href "https://docs.google.com/spreadsheets/d/1Ml_UXDHE4UZo2kjLp1aZLa0KxLtLSnVi/edit?gid=1138387919#gid=1138387919&range=J1:M20"
section AIM 1
section AIM 2
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from Capstone Lines 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_I_8, 2025-03-31, 0d
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH B 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : active, milestone, ADGC1_JK_8, 2025-09-30, 0d
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH C 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_LM_8, 2026-03-31, 0d
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH D 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_NO_8, 2026-10-01, 0d
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH E 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_P_8, 2026-12-31, 0d
Quantify proliferation rates/IF/morphology of IPSC/NPC/Neurons from BATCH F 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_Q_8, 2027-03-31, 0d
Submit L0-L1 from BATCH B, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_LM_111213, 2026-03-31, 0d
Submit L0-L1 from BATCH C, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_NO_111213, 2026-10-01, 0d
Submit L0-L1 from BATCH D, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_P_111213, 2026-12-31, 0d
Submit L0-L1 from BATCH E-G, producing bulk RNA-seq profiles 3 tech reps, 4 bio reps/gene × (20 NPD + 2 ctrl) × 2 (KOLF2.2J/CIRM) iPSC lines; .fastq : crit, milestone, ADGC1_Q_111213, 2027-03-31, 0d
Complete villages - submit L0-L1 to DRACC : crit, milestone, ADGC1_JK_14, 2025-09-30, 0d
Village Analysis - submit L0-L1 to DRACC : crit, milestone, ADGC1_LM_14, 2026-03-31, 0d
Calcium Imaging Capstone Analysis 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_K_15, 2025-09-30, 0d
Calcium Imaging analysis excitatory/inhibitory neurons - Capstone Analysis 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds : crit, milestone, ADGC1_M_15, 2026-03-31, 0d
Calcium Imaging Experiments and analysis of future batches 10 genes, 22 iPSC lines (20 NPD + 2 ctrl) × 2 backgrounds (Submit L0-L4 to DRACC) : crit, milestone, ADGC1_NOPQ_15, 2027-03-31, 0d
section AIM 3
Perform codex Capstone Lines (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_J_161718, 2025-06-30, 0d
Spatial Proteomics Analysis Capstone Lines : crit, milestone, ADGC1_K_161718, 2025-09-30, 0d
Perform codex BATCH B (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_L_161718, 2025-12-31, 0d
Spatial Proteomics Analysis BATCH B : crit, milestone, ADGC1_M_161718, 2026-03-31, 0d
Perform codex BATCH C (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 4 well replicates/line; qptiff format) : crit, milestone, ADGC1_N_161718, 2027-03-31, 0d
Spatial Proteomics Analysis BATCH C : crit, milestone, ADGC1_O_161718, 2027-03-31, 0d
Perform codex and analysis for future batches : crit, milestone, ADGC1_Q_161718, 2027-03-31, 0d
Organoid snRNAseq analysis for Capstone Genes : crit, milestone, ADGC1_J_1920, 2025-06-30, 0d
Perform snRNAseq for BATCH B (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 2-4 organoid replicates/line; tif format) : crit, milestone, ADGC1_K_1920, 2025-09-30, 0d
Organoid snRNAseq analysis for BATCH B : crit, milestone, ADGC1_L_1920, 2025-12-31, 0d
Perform snRNAseq for BATCH C (10 Genes, 20 NPD iPSC lines + 2 control lines) x 2 iPSC background lines; 2-4 organoid replicates/line; tif format) : crit, milestone, ADGC1_M_1920, 2026-03-31, 0d
Organoid snRNAseq analysis C : crit, milestone, ADGC1_N_1920, 2027-03-31, 0d
Perform Integrative analysis across first 30 genes and across experimental modalities (Spatial and snRNAseq). Submit L3-L4 level data by this time at the latest : crit, milestone, ADGC1_O_1920, 2027-03-31, 0d
Perform snRNAseq for future batches : crit, milestone, ADGC1_P_1920, 2026-12-31, 0d
Organoid snRNAseq Analysis for future batches : crit, milestone, ADGC1_Q_1920, 2027-03-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC2 MiNND [RM1MH133065]
section Grant Year
Start Grant Year 3 :milestone, year3_minnd, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
click year3_minnd href "https://docs.google.com/spreadsheets/d/1GNrJaIjs6nPlFY4j2AlZSlTDf2-mi17d/edit?gid=1137576441#gid=1137576441&range=J1:M34"
section Aim 1
section Aim 2
Submit scRNA-seq data for 72 edited lines (3×23 gene mutations + 1 NTC) from last quarter. : active, milestone, ADGC2_J_11, 2025-06-30, 0d
Submit scRNA-seq data for 72 edited lines (3×23 mutations + 1 NTC) & L1-L3 datasets (fastq, RDS, Excel) from last year. : crit, milestone, ADGC2_K_11, 2025-09-30, 0d
Submit scRNA-seq data for 72 edited lines (3×23 mutations + 1 NTC) & L1-L3 datasets (fastq, RDS, Excel) from last quarter : crit, milestone, ADGC2_L_11, 2025-12-31, 0d
Submit scRNA-seq data for 72 edited lines (3×23 mutations + 1 NTC) & L1-L3 datasets (fastq, RDS, Excel) from last quarter : crit, milestone, ADGC2_M_11, 2026-03-31, 0d
Submit Imaging of 72 iPSC lines (3×23 mutations + 1 NTC) & prior quarter L1-L3 : active, milestone, ADGC2_J_12, 2025-06-30, 0d
Submit Imaging of 72 iPSC lines (3×23 mutations + 1 NTC) & prior quarter L1-L3 : crit, milestone, ADGC2_K_12, 2025-09-30, 0d
Submit Imaging of 72 iPSC lines (3×23 mutations + 1 NTC) & prior quarter L1-L3 : crit, milestone, ADGC2_L_12, 2025-12-31, 0d
Submit Imaging of 72 iPSC lines (3×23 mutations + 1 NTC) & prior quarter L1-L3 : crit, milestone, ADGC2_M_12, 2026-03-31, 0d
CODEX 3x data to BIL, generate LoF variants in 1-2 new lines : crit, milestone, ADGC2_M_13, 2026-03-31, 0d
section Aim 3
Submit Synaptic Optical Imaging of 72 iPSC (3×23 mutations + 1 NTC) : active, milestone, ADGC2_J_19, 2025-06-30, 0d
Submit Synaptic Optical Imaging of 72 iPSC (3×23 mutations + 1 NTC) : crit, milestone, ADGC2_K_19, 2025-09-30, 0d
Begin to upload L1-L3 analysis for data from previous year : crit, milestone, ADGC2_K_20, 2025-09-30, 0d
Submit Synaptic Optical Imaging of 72 iPSC (3×23 mutations + 1 NTC) : crit, milestone, ADGC2_L_19, 2025-12-31, 0d
Continue upload L1-L3 analysis for data from previous year : crit, milestone, ADGC2_L_20, 2025-12-31, 0d
Submit Synaptic Optical Imaging of 72 iPSC (3×23 mutations + 1 NTC) : crit, milestone, ADGC2_M_19, 2026-03-31, 0d
Continue upload L1-L3 analysis for data from previous year : crit, milestone, ADGC2_M_20, 2026-03-31, 0d
section Aim4
Submit PatchSeq data for 192 NTC lines L0 data : crit, milestone, ADGC2_J_27, 2025-06-30, 0d
Submit PatchSeq data for 192 NTC lines L0 data : crit, milestone, ADGC2_K_27, 2025-09-30, 0d
Submit PatchSeq data for 192 NTC lines L0 data : crit, milestone, ADGC2_L_27, 2025-12-31, 0d
Submit PatchSeq data for 192 NTC lines L0 data : crit, milestone, ADGC2_M_27, 2026-03-31, 0d
Submit PatchSeq data for 192 cells L1-L3 : crit, milestone, ADGC2_K_28, 2025-09-30, 0d
Submit PatchSeq data for 192 cells L1-L3 : crit, milestone, ADGC2_L_28, 2025-12-31, 0d
Submit PatchSeq data for 192 cells L1-L3 : crit, milestone, ADGC2_M_28, 2026-03-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC3 Yale [RM1MH132648]
section Grant Year
Start Grant Year 3 :milestone, year3_yale, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
click year3_yale href "https://docs.google.com/spreadsheets/d/10xWymZXsDlDQ9uwU5YPAKwyflUMzpDS4/edit?gid=1305684354#gid=1305684354&range=J1:M25"
section Aim 1
Submit initial data (L0, L1) CRISPRi MEA and calcium imaging of 15 ASD genes in iGLUTs and/or iGABAs (ARID1B - SHANK3) : crit, milestone, ADGC3_N_5, 2027-03-31, 0d
Submit initial data (L0, L1) CRISPRi ECCITEseq, KOLF2.2J and CW20107 in iGLUTs (fastq), 10 capstone genes (ARID1B - SMARCC2) : crit, milestone, ADGC3_K_6, 2025-09-30, 0d
Submit initial data (L0, L1) CRISPRi organoid models ECCITEseq of 10 capstone genes (ARID1B - SMARCC2) genes in KOLF2.2J : crit, milestone, ADGC3_N_6, 2027-03-31, 0d
Submit ECCITEseq data (L0, L1) to DRACC for 29 NDD genes (ANK3 - WAC) in induced NPCs, glutamatergic neurons, and GABAergic neurons; iGLUT 3182-3-clone5 (iNPC, d7 iGLUT and d21 iGLUT) and iGABA 553-3-clone34 (d36 iGABA) : done, milestone, ADGC3_I_7, 2025-03-31, 0d
Submit L3/L4 data from iGLUT manuscript : active, milestone, ADGC3_K_7, 2025-09-30, 0d
Submit initial data (L0, L1) iGLUT 10 capstone genes (ARID1B, ASXL3, CACNA1G, CHD8, DLL1, GABRA1, KMT2C, SCN2A, SHANK3, SMARCC2). Across four donors, KOLF2.2J, CW20107, 2607, 553, ECCITEseq resolved 7,985, 3,834, 232, and 8,902 iGLUTs, expected to further increase with final alignments. QC metrics resolved good gRNA representation and high quality/glutamatergic neurons : crit, milestone, ADGC3_Y4_N_4, 2026-06-30, 0d
Submit initial data (L0, L1) CRISPRko calcium imaging of 15 ASD genes in iGLUTs (ARID1B, ASH1L, CHD8, CUL3, DYRK1A, KMT5B, POGZ, PTEN, ANK2, CACNA1G, GRIA3, GRIN2A, NRXN1, SCN2A, SHANK3) and MEA iGLUT (SCN2A) - matrix CSV file : crit, milestone, ADGC3_Y4_N_5, 2026-06-30, 0d
Submit L3/L4 data from manuscript describing capstone ECCITEseq of 10 capstone genes in KOLF2.2J : crit, milestone, ADGC3_Y4_Q_4, 2027-03-31, 0d
Submit L3/L4 data from estradiol pre-print describing calcium imaging of 15 ASD genes and MEA of 1 gene in iGLUTs : crit, milestone, ADGC3_Y4_Q_5, 2027-03-31, 0d
%% For successful screens, submit initial data (L0, L1) CRISPR amplicon-seq of 36/250/whole genome NDD genes for neurogenesis, mitochondrial function, and/or neuronal activity : crit, milestone, ADGC3_Y4_R_6, 2028-03-31, 0d
%% Submit L3/L4 data from manuscript describing phenotyping of all genes across zebrafish + hiPSCs : crit, milestone, ADGC3_Y4_R_7, 2028-03-31, 0d
section Aim 2
Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS), zebrafish, 10 stable mutant lines (ADNP - SYNGAP1) : crit, milestone, ADGC3_I_12, 2025-03-31, 0d
Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS), zebrafish, 20 NPD genes (ANK2 - SMARCC2) : active, milestone, ADGC3_J_14, 2025-06-30, 0d
Submit data (L0, L1) Whole-brain structure and activity mapping (.LIF, .XLS), zebrafish, 5 NPD genes (ADNP - NRXN1) : active, milestone, ADGC3_K_14, 2025-09-30, 0d
Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS), zebrafish, 20 NPD genes (AKAP11 - WAC) : active, milestone, ADGC3_L_14, 2025-12-31, 0d
Submit data (L0, L1) Whole-brain structure and activity mapping (.LIF, .XLS), zebrafish, 5 NPD genes (PPP2R5D - MBD5) : crit, milestone, ADGC3_M_14, 2026-03-31, 0d
Submit L3/L4 data from 40 NPD gene manuscript : crit, milestone, ADGC3_K_15, 2025-09-30, 0d
Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS), zebrafish, 20 NPD genes (CASKIN1 - XPO7) : crit, milestone, ADGC3_N_15, 2027-03-31, 0d
Submit data (L0, L1) Whole-brain RNA-seq, zebrafish, 10 NPD genes (CHD8 - SMARCC2) : crit, milestone, ADGC3_N_17, 2027-03-31, 0d
Submit data (L0, L1) Whole-brain RNA-seq, zebrafish, 10 genes, including 9 pilot "capstone" genes - ARID1B, CACNA1G, CHD8, DLL1, GABRA1, KMT2C, SCN2A, SHANK3, SMARCC2, PTEN : crit, milestone, ADGC3_Y4_N_14, 2026-06-30, 0d
Submit data (L0, L1) Whole-brain structure and activity mapping, zebrafish, 5 NPD genes (FMR1, DLL1, KCNQ3, SHANK3, SMARCC2) : crit, milestone, ADGC3_Y4_O_14, 2026-09-30, 0d
Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS) for 20 NPD genes (CASKIN1, CTCF, DEAF1, DYNC1H1, EBF3, FMR1, GIGYF1, HERC1, KCNMA1, IRF2BPL, MECP2, MED13L, NF1, RB1CC1, SETD1A, SP4, TANC2, TAOK1, TCF20, TCF7L2) : crit, milestone, ADGC3_Y4_P_14, 2026-12-31, 0d
Submit data (L0, L1) Whole-brain structure and activity mapping, zebrafish, 5 NPD genes (CHD2, GIGYF1, KMT2C, MECP2, CACNA1G) : crit, milestone, ADGC3_Y4_Q_14, 2027-03-31, 0d
Submit data (L0, L1) Whole-brain RNA-seq, zebrafish, 10 NPD genes (ADNP, ASH1L, CHD2, DLG4, DYRK1A, MECP2, NRXN1, POGZ, PPP2R5D, SYNGAP1) : crit, milestone, ADGC3_Y4_Q_15, 2027-03-31, 0d
Submit L3/L4 data from manuscript describing phenotyping of first 40 NPD genes : crit, milestone, ADGC3_Y4_Q_17, 2027-03-31, 0d
%% Submit data (L0, L1) High-throughput quantitative behavioral profiling (.raw, .XLS), zebrafish, 20 NPD genes. : crit, milestone, ADGC3_Y4_R_15, 2028-03-31, 0d
%% Submit data (L0, L1) Whole-brain structure and activity mapping, zebrafish, 10 NPD genes. : crit, milestone, ADGC3_Y4_R_16, 2028-03-31, 0d
%% Submit data (L0, L1) Whole-brain RNA-seq, zebrafish, 20 NPD genes : crit, milestone, ADGC3_Y4_R_17, 2028-03-31, 0d
%% Submit L3/L4 data from manuscript describing phenotyping of all genes across zebrafish + hiPSCs : crit, milestone, ADGC3_Y4_R_19, 2028-03-31, 0d
section Aim 3
Submit data (L0, L1) Transcriptomic and epigenomic analysis 5 DBiT RNA-seq, 5 DBiT ATAC-seq, zebrafish CHD8 : crit, milestone, ADGC3_M_22, 2026-03-31, 0d
Submit data (L0, L1) Transcriptomic and epigenomic analysis 10-20 DBiT RNA-seq and DBiT ATAC-seq profiles, zebrafish 2 TBD genes : crit, milestone, ADGC3_N_22, 2027-03-31, 0d
Submit data (L0, L1) CRISPRi organoid transcriptomic and epigenomic analysis 5-10 DBiT RNA-seq profiles and DBiT ATAC-seq profiles, CHD8 : crit, milestone, ADGC3_M_23, 2026-03-31, 0d
Submit data (L0, L1) CRISPRi organoid transcriptomic and epigenomic analysis 10-20 DBiT RNA-seq and DBiT ATAC-seq, two TBD genes : crit, milestone, ADGC3_N_23, 2027-03-31, 0d
Submit data (L0, L1) Transcriptomic and epigenomic analysis (10-20 DBiT RNA-seq profiles (fastq) and 10-20 DBiT ATAC-seq profiles (fastq)), zebrafish, two NPD genes (TBD, possibly CHD8, SCN2A, SHANK3). : crit, milestone, ADGC3_Y4_Q_20, 2027-03-31, 0d
Submit data (L0, L1) CRISPRko organoid Perturb-DBIT (4-8 DBiT RNA-seq profiles (fastq)), calcium imaging, and matched single cell ECCITEseq, across developmental timepoints and 36 pooled NPD genes : crit, milestone, ADGC3_Y4_Q_21, 2027-03-31, 0d
%% Submit L3/L4 data from manuscript describing spatial transcriptomic analysis of NPD genes in zebrafish : crit, milestone, ADGC3_Y4_R_20, 2028-03-31, 0d
%% Submit L3/L4 data from manuscript describing integration of spatial and single-cells pooled CRISPRko organoid NDD gene analysis : crit, milestone, ADGC3_Y4_R_21, 2028-03-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC4 Broad [R01MH128366]
section Grant Year
Start Grant Year 3 :milestone, year3_broad, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
click year3_broad href "https://docs.google.com/spreadsheets/d/1BwaO6rgn0o5nTulC2M6dQe5UMGUWEy-o/edit?gid=2037309850#gid=2037309850&range=D1:D16"
section Aim 1
Submit 100,000 scRNA-seq profiles per cell type (fastq) of 191 genes in 3 cell types : crit, milestone, ADGC4_Aim1_year4_E_3, 2026-03-31, 0d
Submit image dataset of 120 TB (443 genes in 3 cells 5 million profiles) : crit, milestone, ADGC4_Aim1_year4_E_4, 2026-03-31, 0d
Submit remaining image datasets : crit, milestone, ADGC4_Aim1_year5_item1, 2027-03-31, 0d
section Aim 2
Submit 100,000 scRNA-seq profiles per cell type of 191 genes in 3 cell types (fastq) : crit, milestone, ADGC4_Aim2_year4_E_9, 2026-03-31, 0d
Submit 50 TB of calcium imaging and MERFISH data : done, milestone, ADGC4_Aim2_year3_D_11, 2025-03-31, 0d
Submit 5 TB of optical electrophysiology data - DATA QUALITY BEING ASSESSED : crit, milestone, ADGC4_Aim2_year3_D_10, 2026-03-31, 0d
Submit 5 TB of optical electrophysiology data : crit, milestone, ADGC4_Aim2_year4_E_10, 2026-03-31, 0d
Submit remaining optical electrophysiology data : crit, milestone, ADGC4_Aim2_year5_item1, 2027-03-31, 0d
section Aim 3
Submit RNA-seq profiles - ANALYSIS / SUBMISSION UNDERWAY : active, milestone, ADGC4_Aim3_year3_D_15, 2025-03-31, 0d
Submit RNA-seq profiles from >10,000 cells : crit, milestone, ADGC4_Aim3_year4_E_15, 2026-03-31, 0d
Submit remaining RNA-seq profiles : crit, milestone, ADGC4_Aim3_year5_item1, 2027-03-31, 0d
Submit 10 TB of associated images to DRACC : crit, milestone, ADGC4_Aim3_year4_D_16, 2026-03-31, 0d
Submit remaining morphology imaging : crit, milestone, ADGC4_Aim3_year5_item2, 2027-03-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC5 Scripps/Broad [R01MH137042-01/-02]
section Grant Year
Start Grant Year 3 :milestone, m1, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
section Scripps/Broad Reporting Year
End Scripps/Broad Reporting Year 1 :milestone, year1_scripps, 2025-03-31, 0d
End Scripps/Broad Reporting Year 2 :milestone, m1, 2026-03-31, 0d
End Scripps/Broad Reporting Year 3 :milestone, m1, 2027-03-31, 0d
click year1_scripps href "https://docs.google.com/spreadsheets/d/19RWN6-DjIyMpFV2JP4yY5Ta5Xfthieds/edit?gid=744607405#gid=744607405&range=C2:C15"
section Aim 1
Generate multiomics data for 50 genes in 1 brain region at 1 time point : V_Y2t1, 2025-03-31,52w
Submit L0/L1 data to DRACC (Restricted) 175 FASTQ for 75TB overall : crit, milestone, ADGC5_Aim1_year4_item1, 2026-03-31, 0d
section Aim 2
Generate raw TIFF format and 3D swc files for 100 neurons on 3 genes : V_Y2t7, 2025-03-31,52w
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC6 Cross-Scale Interrogation of NPD Genes (SING) - PSU/JAX/UTSW/NYU [RM1MH138309]
section Grant Year
Start Grant Year 3 :milestone, m1, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
section SING Reporting Year
End SING Reporting Year 1 :milestone, year1_SING, 2025-12-31, 0d
End SING Reporting Year 2 :milestone, m1, 2026-12-31, 0d
click year1_SING href "https://docs.google.com/spreadsheets/d/1pw1muwglklo-gXrC5hadYjSqBjhZOKeh/edit?gid=1827916005#gid=1827916005&range=C2:E23"
section Aim 1
DRACC data transfer of C57 control MERFISH : crit, milestone, ADGC6_D_8, 2025-09-30, 0d
DRACC data transfer of first 5 KO mice MERFISH data : crit, milestone, ADGC6_E_7, 2025-12-31, 0d
DRACC data transfer of 2025 Q4 and 2026 Q1-Q3 KO mice MERFISH data : crit, milestone, ADGC6_F_7, 2026-12-31, 0d
DRACC data transfer of C57 control 10x Flex : crit, milestone, ADGC6_D_10, 2025-09-30, 0d
DRACC data transfer of 10x Flex from 2025 and 2026Q1-Q2 : crit, milestone, ADGC6_F_10, 2026-12-31, 0d
DRACC data transfer of C57 control L0 1TB, L1 0.5TB spatial txn : crit, milestone, ADGC6_Y2_B_4, 2026-03-31, 0d
DRACC data transfer of 1st-4th KO L0 4TB, L1 2TB spatial txn : crit, milestone, ADGC6_Y2_C_5, 2026-06-30, 0d
DRACC data transfer of 1st-4th scRNA-seq L0 0.8TB data, L1 0.4TB : crit, milestone, ADGC6_Y2_D_6, 2026-09-30, 0d
DRACC data transfer of 5th-8th KO L0 4TB, L1 2TB spatial txn : crit, milestone, ADGC6_Y2_D_7, 2026-09-30, 0d
DRACC data transfer of 5th-8th line scRNA-seq L0 0.8TB data, L1 0.4TB : crit, milestone, ADGC6_Y2_E_6, 2026-12-31, 0d
DRACC data transfer of 9th - 12th KO L0 4TB, L1 2TB spatial txn : crit, milestone, ADGC6_Y2_E_7, 2026-12-31, 0d
section Aim 2
DRACC data transfer of C57 control MRI and LSFM data : active, milestone, ADGC6_D_16, 2025-09-30, 0d
DRACC data transfer of first 5 KO mice MRI and LSFM data : active, milestone, ADGC6_E_16, 2025-12-31, 0d
DRACC data transfer of 2025 Q4 and 2026 Q1-Q3 KO mice MRI and LSFM data : crit, milestone, ADGC6_F_16, 2026-12-31, 0d
DRACC data transfer of 1st-5th MRI L0 0.24TB data, L1 0.2TB, initial analysis 20 mouse brains : crit, milestone, ADGC6_Y2_B_11, 2026-03-31, 0d
DRACC data transfer of 6th-10th MRI L0 0.5TB data, L1 0.5TB : crit, milestone, ADGC6_Y2_C_11, 2026-06-30, 0d
DRACC data transfer of 6th-10th LSFM L1 5TB data, L2 0.5TB CCF mapped 1st-5th lines : crit, milestone, ADGC6_Y2_C_15, 2026-06-30, 0d
DRACC data transfer of 11th-15th MRI L0 0.5TB data, L1 0.5TB : crit, milestone, ADGC6_Y2_D_11, 2026-09-30, 0d
DRACC data transfer of 16th-20th MRI L0 0.5TB data, L1 0.5TB : crit, milestone, ADGC6_Y2_E_11, 2026-12-31, 0d
DRACC data transfer of 16th-20th LSFM L1 5TB data, L2 0.5TB CCF mapped 11th-15th lines : crit, milestone, ADGC6_Y2_E_15, 2026-12-31, 0d
section Aim 3
DRACC data transfer of C57 control behavioral data : active, milestone, ADGC6_D_23, 2025-09-30, 0d
DRACC data transfer of first 5 KO lines behavioral data : crit, milestone, ADGC6_E_23, 2025-12-31, 0d
DRACC data transfer of 2025 Q4 and 2026 Q1-Q3 KO line behavioral data : crit, milestone, ADGC6_F_23, 2026-12-31, 0d
DRACC data transfer of L0 Video, L1 tracking behavior from lines : crit, milestone, ADGC6_Y2_B_22, 2026-03-31, 0d
DRACC data transfer of L0 Video, L1 tracking behavior from lines : crit, milestone, ADGC6_Y2_C_22, 2026-06-30, 0d
DRACC data transfer of L0 Video, L1 tracking behavior from lines : crit, milestone, ADGC6_Y2_D_22, 2026-09-30, 0d
DRACC data transfer of L0 Video, L1 tracking behavior from lines : crit, milestone, ADGC6_Y2_E_22, 2026-12-31, 0d
gantt
dateFormat YYYY-MM-DD
axisFormat %Y-Q%q
title ADGC7 Washington Univ. St Louis - WUSTL [RM1MH138313]
section Grant Year
Start Grant Year 3 :milestone, m1, 2025-03-31, 0d
Start Grant Year 4 :milestone, m1, 2026-03-31, 0d
Start Grant Year 5 :milestone, m1, 2027-03-31, 0d
section WUSTL Reporting Year
End WUSTL Reporting Year 1 :milestone, year1_wustl, 2025-12-31, 0d
End WUSTL Reporting Year 2 :milestone, m1, 2026-12-31, 0d
click year1_wustl href "https://docs.google.com/spreadsheets/d/1ae4bX4Ful2AWlqzeH_JOo4jFssmEsojd/edit?gid=1888128068#gid=1888128068&range=C2:E27"
section Aim 1
L0, L1 Data from last quarter submitted, and 3 more lines collected : crit, milestone, ADGC7_E_12, 2025-12-31, 0d
L0, L1 Data from last quarter submitted, and 4 more lines collected : crit, milestone, ADGC7_F_12, 2026-03-31, 0d
L2, L3 from prior L0,L1 data submitted : crit, milestone, ADGC7_F_13, 2026-03-31, 0d
L0, L1 Data from lines 1-2 submitted : crit, milestone, ADGC7_Y2_C_12, 2026-06-30, 0d
L2, L3 from lines 1-2 submitted : crit, milestone, ADGC7_Y2_D_12, 2026-09-30, 0d
L0, L1 Data from lines 3-5 submitted : crit, milestone, ADGC7_Y2_D_13, 2026-09-30, 0d
L2, L3 from lines 3-5 submitted : crit, milestone, ADGC7_Y2_E_13, 2026-12-31, 0d
L0, L1 Data from lines 6-10 submitted : crit, milestone, ADGC7_Y2_E_14, 2026-12-31, 0d
%% snRNAseq collected for lines 15-30 and data submitted one quarter post collection, L2 and L3 data submitted 2 quarters post collection : crit, milestone, ADGC7_Y2_F_12, 2027-12-31, 0d
%% L0, L1 Data from lines 11-14 submitted : crit, milestone, ADGC7_Y2_F_13, 2027-12-31, 0d
%% L2, L3 from lines 6-10 submitted : crit, milestone, ADGC7_Y2_F_14, 2027-12-31, 0d
section Aim 2
Home Cage Behavior L0-L1 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_C_17, 2025-06-30, 0d
Home Cage Behavior L3 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_D_18, 2025-09-30, 0d
Home Cage Behavior L4 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_E_19, 2025-12-31, 0d
Home Cage Behavior L0-L1 Data to DRACC for line 3-4 : crit, milestone, ADGC7_D_17, 2025-09-30, 0d
Home Cage Behavior L3 Data to DRACC for lines 3-4 : crit, milestone, ADGC7_E_18, 2025-12-31, 0d
%% Home Cage Behavior L4 Data to DRACC for lines 3-4 : crit, milestone, ADGC7_F_19, 2026-03-31, 0d
Home Cage Behavior L4 Data to DRACC for lines 3-4: crit, milestone, ADGC7_Y2_B_19, 2026-03-31, 0d
Home Cage Behavior L0-L1 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_E_17, 2025-12-31, 0d
%% Home Cage Behavior L3 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_F_18, 2026-03-31, 0d
Home Cage Behavior L3 Data to DRACC for lines 5-7: crit, milestone, ADGC7_Y2_B_18, 2026-03-31, 0d
Home Cage Behavior L4 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_Y2_C_19, 2026-06-30, 0d
Home Cage Behavior L0-L1 Data to DRACC for lines 8-12: crit, milestone, ADGC7_Y2_B_17, 2026-03-31,
Home Cage Behavior L3 Data to DRACC for line 8-12 : crit, milestone, ADGC7_Y2_C_18, 2026-06-30, 0d
Home Cage Behavior L4 Data to DRACC for lines 8-12 : crit, milestone, ADGC7_Y2_D_19, 2026-09-30, 0d
Home Cage Behavior L0-L1 Data to DRACC for lines 13-16 : crit, milestone, ADGC7_Y2_C_17, 2026-06-30, 0d
Home Cage Behavior L3 Data to DRACC for line 13-16 : crit, milestone, ADGC7_Y2_D_18, 2026-09-30, 0d
Home Cage Behavior L4 Data to DRACC for lines 13-16 : crit, milestone, ADGC7_Y2_E_19, 2026-12-31, 0d
Home Cage Behavior L0-L1 Data to DRACC for lines 17-22 : crit, milestone, ADGC7_Y2_D_17, 2026-09-30, 0d
Home Cage Behavior L3 Data to DRACC for line 17-22 : crit, milestone, ADGC7_Y2_E_18, 2026-12-31, 0d
%% Home Cage Behavior L4 Data to DRACC for lines 17-22 : crit, milestone, ADGC7_Y2_F_19, 2027-12-31, 0d
Home Cage Behavior L0-L1 Data to DRACC for lines 23-27 : crit, milestone, ADGC7_Y2_E_17, 2026-12-31, 0d
%% Home Cage Behavior L3 Data to DRACC for line 23-27 : crit, milestone, ADGC7_Y2_F_18, 2027-12-31, 0d
%% Home Cage Behavior L0-L1 data to DRACC for lines 28-32 : crit, milestone, ADGC7_Y2_F_17, 2027-12-31, 0d
IB & SI L0 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_C_20, 2025-06-30, 0d
IB & SI L1 & L3 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_D_20, 2025-09-30, 0d
IB & SI L4 Data to DRACC for lines 1-2 : crit, milestone, ADGC7_E_20, 2025-12-31, 0d
IB & SI L0 Data to DRACC for lines 3-4 : crit, milestone, ADGC7_D_21, 2025-09-30, 0d
IB & SI L1 & L3 Data to DRACC for line 3-4 : crit, milestone, ADGC7_E_21, 2025-12-31, 0d
%% IB & SI L4 Data to DRACC for lines 3-4 : crit, milestone, ADGC7_F_21, 2026-03-31, 0d
IB & SI L4 Data to DRACC for lines 3-4 : crit, milestone, ADGC7_Y2_B_20, 2026-03-31, 0d
IB & SI L0 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_E_22, 2025-12-31, 0d
%% IB & SI L1 & L3 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_F_22, 2026-03-31, 0d
IB & SI L1 & L3 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_Y2_B_21, 2026-03-31, 0d
IB & SI L4 Data to DRACC for lines 5-7 : crit, milestone, ADGC7_Y2_C_20, 2026-06-30, 0d
IB & SI L0 Data to DRACC for lines 8-12 : crit, milestone, ADGC7_Y2_B_22, 2026-03-31, 0d
IB & SI L1 & L3 Data to DRACC for line 8-12 : crit, milestone, ADGC7_Y2_C_21, 2026-06-30, 0d
IB & SI L4 Data to DRACC for lines 8-12 : crit, milestone, ADGC7_Y2_D_20, 2026-09-30, 0d
IB & SI L0 Data to DRACC for lines 13-16 : crit, milestone, ADGC7_Y2_C_22, 2026-06-30, 0d
IB & SI L1 & L3 Data to DRACC for line 13-16 : crit, milestone, ADGC7_Y2_D_21, 2026-09-30, 0d
IB & SI L4 Data to DRACC for lines 13-16 : crit, milestone, ADGC7_Y2_E_20, 2026-12-31, 0d
IB & SI L0 Data to DRACC for lines 17-22 : crit, milestone, ADGC7_Y2_D_22, 2026-09-30, 0d
IB & SI L1 & L3 Data to DRACC for line 17-22 : crit, milestone, ADGC7_Y2_E_21, 2026-12-31, 0d
IB & SI L0 Data to DRACC for lines 23-27 : crit, milestone, ADGC7_Y2_E_22, 2026-12-31, 0d
%% IB & SI L4 Data to DRACC for lines 17-22 : crit, milestone, ADGC7_Y2_F_20, 2027-12-31, 0d
%% IB & SI L1 & L3 Data to DRACC for line 23-27 : crit, milestone, ADGC7_Y2_F_21, 2027-12-31, 0d
%% IB & SI L0 Data to DRACC for lines 28-32 : crit, milestone, ADGC7_Y2_F_22, 2027-12-31, 0d
section Aim 3
%% Imaging L0, L1 data collected for 3 lines : crit, milestone, ADGC7_D_27, 2025-09-30, 0d
L0, L1 Data from last quarter submitted, and 4 more lines collected : crit, milestone, ADGC7_E_27, 2025-12-31, 0d
%% L0, L1 Data from last quarter submitted, and 4 more lines collected : crit, milestone, ADGC7_F_27, 2026-03-31, 0d
L2, L3 from prior L0,L1 data submitted : crit, milestone, ADGC7_F_28, 2026-03-31, 0d
L0, L1 Data from lines 1-3 submitted : crit, milestone, ADGC7_Y2_B_27, 2026-03-31, 0d
L2, L3 from lines 1-3 submitted : crit, milestone, ADGC7_Y2_C_27, 2026-06-30, 0d
L0, L1 Data from lines 4-6 submitted : crit, milestone, ADGC7_Y2_C_28, 2026-06-30, 0d
L2, L3 from lines 4-6 submitted : crit, milestone, ADGC7_Y2_D_28, 2026-09-30, 0d
L0, L1 Data from lines 7-11 submitted : crit, milestone, ADGC7_Y2_D_29, 2026-09-30, 0d
L2, L3 from lines 7-11 submitted : crit, milestone, ADGC7_Y2_E_29, 2026-12-31, 0d
L0, L1 Data from lines 11-15 submitted : crit, milestone, ADGC7_Y2_E_30, 2026-12-31, 0d
%% Spatial collected for lines 20-40 and data submitted one quarter post collection, L2 and L3 data submitted 2 quarters post collection : crit, milestone, ADGC7_Y2_F_28, 2027-12-31, 0d
%% L0, L1 Data from lines 16-20 submitted : crit, milestone, ADGC7_Y2_F_29, 2027-12-31, 0d
%% L2, L3 from lines 11-15 submitted : crit, milestone, ADGC7_Y2_F_30, 2027-12-31, 0d