Description

COSMIC, the "Catalogue Of Somatic Mutations In Cancer," is an online database of somatic mutations found in human cancer. Focused exclusively on non-inherited acquired mutations, COSMIC combines information from a range of sources, curating the described relationships between cancer phenotypes and gene (and genomic) mutations. This data is then made available in a number of ways including here in the UCSC genome browser, on the COSMIC website with custom analytical tools, or via the COSMIC sftp server. Publications using COSMIC as a data source may cite any of our references below.

Methods

This track was built from the COSMIC v81 data release.

The data in COSMIC is curated from a number of high-quality sources and combined into a single resource. The sources include:

Information on known cancer genes, selected from the Cancer Gene Census is curated manually to maximise its descriptive content.

The data was downloaded from the COSMIC sftp server. It was first converted to a bed file using the UCSC utility cosmicToBed, then converted into a bigBed file using the UCSC utility bedToBigBed. The bigBed file is used to generate the track.

Display

Contacts

For further information on COSMIC, or for help with the information provided, please contact cosmic@nullsanger.ac.uk.

References

Forbes SA, Bhamra G, Bamford S, Dawson E, Kok C, Clements J, Menzies A, Teague JW, Futreal PA, Stratton MR. The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet. 2008 Apr;Chapter 10:Unit 10.11. PMID: 18428421; PMC: PMC2705836

Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, Jia M, Shepherd R, Leung K, Menzies A et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50. PMID: 20952405; PMC: PMC3013785