UCSC Ebola Genome Portal: Antibody Resources

Antibody Resources

This section contains links to papers and other resources related to antibody use in the treatment and vaccine development for Ebola Virus Disease.

Neutralizing antibodies for Kikwit strain (1999): Ebola virus can be effectively neutralized by antibody produced in natural human infection [PDF]

Humanized mAbs (ZMapp) expressed in tobacconists (2014): Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp [PDF]

mAbs (MB-003) cocktail (2012): Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

EBOV IgG+ sera from asymptomatic individuals and symptomatic Gabonese survivors (2014): Identification of continuous human B-cell epitopes in the VP35, VP40, nucleoprotein and glycoprotein of Ebola virus [PDF]

Mouse mAb binding sites mapped to seven antigenic regions, two highly conserved, across all known Ebolavirus species (2013): Mapping of conserved and species-specific antibody epitopes on the Ebola virus nucleoprotein [PDF]

Literature links from Reported functional EBOV-related B cell epitopes (Table 2) on the Immune Epitope Database and Analysis Resource (IEDB) website:

Additional references and detail for above are in our working spreadsheet below.